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手足口病是在东南亚,特别是在中国大规模频繁爆发的疾病,柯萨奇病毒A16型以及肠道病毒71型是引起感染的主要致病病原体,其中EV71感染不仅造成轻症病例,还能造成重症和死亡病例,也是在我国目前的主要致病原。目前我国已有EV71灭活疫苗上市,但疫苗本身存在一定程度风险且不能预防所有的手足口病。当前对于感染仅仅可以使用一些常用的广谱抗病毒药物进行支持性治疗。本文针对目前引起手足口病的EV71的小分子抑制剂的合成研究进展进行了综述,为治疗人手足口病的药物研发提供参考。
Hand, foot and mouth disease is a large-scale and frequent outbreak of disease in Southeast Asia, especially in China. Coxsackievirus A16 and enterovirus 71 are the major causative pathogens causing infection. EV71 infection not only causes mild cases but also mild Cause severe cases and deaths, is also the main pathogen in our country at present. At present, China has EV71 inactivated vaccine market, but the vaccine itself has a certain degree of risk and can not prevent all hand, foot and mouth disease. Currently, only a few commonly used broad-spectrum antiviral drugs are available for supportive care. This article reviews the current progress in the synthesis of small molecule inhibitors of EV71 that cause hand-foot-mouth disease, and provides a reference for the drug development of hand, foot and mouth disease.