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目的:观察复方硫酸氢黄连素灌肠液比单方黄连素制剂抗菌活性是否有所增加。方法:采用琼脂平板稀释法和平皿法,并以志贺氏痢疾杆菌感染小鼠为动物模型,测定复方硫酸氢黄连素灌肠液的体内、体外抗菌活性。结果:复方制剂比单方制剂的MIC和MBC分别降低1～125倍和1～15倍,抑菌环增大,敏感性增强,体内感染细菌小鼠死亡率降低。结论:复方硫酸氢黄连素灌肠液对常见细菌感染比单方黄连素制剂具有较强的抗感染作用。
Objective: To observe whether the antibacterial activity of compound hydrogen sulfate berberine enema than unilateral berberine preparation increased. Methods: Agar plate dilution method and plate method, and Shiga Shigella infection in mice as an animal model to determine compound bisulfate berberine enema in vivo and in vitro antibacterial activity. Results: The MIC and MBC of compound prescription were reduced by 1 ~ 125 times and 1 ~ 15 times respectively than those of unilateral prescription. The inhibitory ring increased and the sensitivity increased. The mortality of bacterial in vivo infected mice decreased. Conclusion: The compound hydrogen sulfate berberine enema has a stronger anti-infective effect on the common bacterial infection than the unicorin.