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为了认识慢性HBV感染的坏死炎症发生的重要性,对HBsAg携带者或无HBsAg的黑猩猩用另一些重要的嗜肝病毒使其发生感染,以便评价组织学、病毒学和生物化学标志的改变.在黑猩猩中进行研究的优点是可取得在人体得不到的连续活组织样本和病毒性的特殊性的组织学损害.感染甲型和非甲非乙型肝炎在慢性HBsAg携带者黑猩猩中比不携带者的损害更严重.在这种重叠感染期间,第二种病毒的特定表达占优势,提示第二种病毒加剧了损伤,但携带者比非携带者的黑猩猩易于发生较严重的损害.
To understand the importance of the occurrence of necrotic inflammation in chronic HBV infection, chimpanzees with HBsAg or HBsAg are challenged with other important hepadnaviruses to evaluate histological, virological, and biochemical changes The advantage of doing research in chimpanzees is that they can achieve the histological damage of continuous biopsy samples and virulence not available in the human body.Infection of A and non-A non-B hepatitis in chronic chickens with HBsAg chimpanzees than not carrying Of the second virus during this overlapping infection, suggesting that the second virus exacerbates the injury, but carriers are more susceptible to more severe damage than non-carriers of chimpanzees.