论文部分内容阅读
测定了492例正常妊娠、12例神经管缺损(NTD)和15例其它异常妊娠的羊水总胆碱酯酶(TChE)和真性胆碱酯酶(AChE)活性。正常妊娠的羊水TChE及AChE活性(x±s)分别为5.36±3.11和2.67±1.55U/L;NTD分别为20.97±9.21和8.83±5.09U/L,后者比前者显著升高(P<0.05)。但都有不同程度的交叉。结果表明:①TChE及AChE-AChE/TChE判别分析均可作为NTD的诊断指标,前者的分割点为13U/L,后者的临界值为2×10~(-3)(判别函数式:9.94×10~(-4)·AChE-76.68×10~(-4)·AChE/TChE)。②羊水AChE诊断NTD的假阴性率太高,不适作为诊断指标。@TChE/AChE比值升高对NTD与脐膨出具有宫内鉴别诊断意义。
The total amniotic fluid total cholinesterase (TChE) and true cholinesterase (AChE) activity were measured in 492 normal pregnant women, 12 with neural tube defects (NTD) and 15 with other abnormal pregnancies. The normal pregnancy TChE and AChE activity (x ± s) were 5.36 ± 3.11 and 2.67 ± 1.55U / L, NTD were 20.97 ± 9.21 and 8.83 ± 5.09U / L respectively, the latter was significantly higher than the former (P < 0.05). But all have different degrees of crossover. The results showed that: ①TChE and AChE-AChE / TChE discriminant analysis can be used as a diagnostic indicator of NTD, the former of the partition point of 13U / L, the latter of the critical value of 2 × 10 ~ (-3) (discriminant function: 9.94 × 10 -4 (AChE-76.68 × 10 -4 (AChE / TChE)). ② amniotic fluid AChE diagnosis of NTD false-negative rate is too high, not as a diagnostic indicator. @ TChE / AChE ratio of NTD and umbilical swelling with intrauterine differential diagnosis.