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To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to SRS
To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery (SRS) using invasive fixation. Subjects in 87patients who had 4or more brain Treatments were performed on 159meta stases by using a linac-based stereotactic system. T he median isocentric dose was 35 Gy in 4fractions. Well-brain irradiati on was not applied as an initial treatment. For the salvage treatmen t of metachronous brain metastases, repeat HSRT or whole-brain irradiation was applied. The actuarial 1-year local tumor control rate was 81%. Treatment-related complications were observed in 4patients in the ely period (<3months) and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients, and none of the 18patients who were eligible for salvage HSRT ref used to re ceive it again. Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported in the literature. results of that that suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness to SRS