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Purpose: To study cyelosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs. Methods : To study the growth curve of cyelosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyelosporine A combined with seven antineoplastic drugs. Results: The average IC50 of cyelosporine A on the 27 retinoblastoma cells is 67.81μg/ ml and the average inhibitive rate of these samples is 26.1% when cyelosporine A is in the concentration of 2μg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyelosporine A and the increasing average inhibitive rate is more than 5. Conclusion: Cyelosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells. Eye Science 2005;21;62-66.
To: the study of growth growth of cyelosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyelosporine A combined with seven antineoplastic drugs. Results: The average IC50 of cyelosporine A on the 27 retinoblastoma cells is 67.81 μg / ml and the average inhibitive rate of these samples is 26.1% when cyelosporine A is in the concentration of 2 μg / ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyelosporine A and the increasing average inhibitive rate is more than 5. Conclusion: Cyanosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells. Eye Science 2005; 21; 62-66 .