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Purpose: To determine the distribution of the toxin among individual muscles after intramuscular injection of botulinum toxin gel. Methods: One eye of 7 New Zealand white rabbits was randomized into group A, and the contralateral eye was into group B. Eyes in group A received medial rectus intramuscular injection of 2.5 IU of 125I-BTX-A gel in 0.1ml, and those in group B received equivalent amount of 125I-BTX-A solution by medial rectus intramuscular injection. Four rectus muscles and the levator palpebrae superioris were harvested and the radioactivity of muscles was measured 16 hours after the injection. Results: In group A, the radioactivity of per gram medial rectus was significantly higher than that of other muscles (P < 0.01), and there was no statistically significant difference in the radioactivity of per gram muscles among other muscles (P> 0.05). In group B, the radioactivity of per gram medial rectus and levator palpebrae superioris was significantly higher than that of other muscles respectiv
Purpose: To determine the distribution of the toxin among individual muscles after intramuscular injection of botulinum toxin gel. Methods: One eye of 7 New Zealand white rabbits was randomized into group A, and the contralateral eye was into group B. Eyes in group A received medial rectus intramuscular injection of 2.5 IU of 125I-BTX-A gel in 0.1 ml, and those in group B received equivalent amount of 125I-BTX-A solution by medial rectus intramuscular injection. Four rectus muscles and the levator palpebrae superioris were harvested and the radioactivity of muscles was measured 16 hours after the injection. Results: In group A, the radioactivity of per gram medial rectus was significantly higher than that of other muscles (P <0.01), and there was no significant significant difference in the radioactivity of per gram muscles among other muscles (P> 0.05). In group B, the radioactivity of per gram medial rectus and levator palpebrae superioris was significantly higher than that of othe r muscles respectiv