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肺的解剖位置和构造决定了它能极好地完成呼吸功能。同时肺又是机体内唯一有全部血液通过的脏器,其细胞种类繁多、含酶丰富、代谢活跃,在调节全身器官及内环境稳定方面起重大作用。肺代谢紊乱不仅是呼吸功能衰竭的表现和起因,而且也常常成为多系统器官衰竭的触发因素。氧的利用和能量代谢肺的能量来自于氧化代谢,底物主要为葡萄糖。氧一方面从动脉血中获取,另一方面由肺泡气直接弥散,其深度可达组织50微米。底物首先在细胞浆中经脱氢酶系作用生成NADPH(还原型尼克酰胺腺嘌呤二核苷酸磷酸)、NADH(还原型尼克酰胺腺嘌呤二核苷酸)、和FADH_2(还原型黄素嘌呤
The anatomy and anatomy of the lungs determine how well it performs its breathing function. At the same time, the lung is the only organ in the body with all the blood passing through. Its various cells, rich in enzymes and active metabolites, play a significant role in the regulation of whole body organs and the stability of the internal environment. Pulmonary metabolic disorders are not only a manifestation and cause of respiratory failure, but are also often triggers for multi-system organ failure. Oxygen utilization and energy metabolism Lung energy comes from oxidative metabolism, the substrate is mainly glucose. Oxygen is obtained on the one hand from arterial blood and on the other hand is directly dispersed by alveolar gas at a depth of up to 50 μm. Substrates first undergo NADPH (reduced nicotinamide adenine dinucleotide phosphate), NADH (reduced nicotinamide adenine dinucleotide), and FADH_2 (reduced type flavin Purine