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目的：探讨脂质过氧化和中分子物质在兔实验性急性油酸肺损伤中的作用以及山莨菪碱和肠道吸附剂对油酸肺损伤的防治效应。方法：１８ 只兔由耳缘静脉注入油酸０．１ ｍ ｌ／ｋｇ 体重形成急性肺损伤模型，其中１０ 只以山莨菪碱１０ ｍ ｇ／ｋｇ 体重和肠道吸附剂１ ｇ／ｋｇ 体重分别处理（各５ 只）作为处理组，另８只作为实验组。结果：油酸组与生理盐水对照组相比，全血超氧化物歧化酶（ＳＯＤ）和支气管肺泡灌洗液（ＢＡＬＦ）中谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力显著减低（Ｐ＜ ０．０５ 和Ｐ＜ ０．０１）；血浆和ＢＡＬＦ中的丙二醛（ＭＤＡ）和丙二醛与脂质系数（ＭＤＡ／Ｌｉｐｉｄ）均明显增加（Ｐ＜ ０．０５～０．０１）；ＢＡＬＦ中的ＡＬＰ、ＡＬＢ和肺系数都显著增加（Ｐ＜ ０．０１）；血浆和ＢＡＬＦ中的ＭＭＳ也显著增加（Ｐ＜ ０．０１）。山莨菪碱组和肠道吸附剂组分别与油酸组相比，ＳＯＤ与ＧＳＨ－Ｐｘ 活力均增加（Ｐ＜０．０５～０．０１）；除了血浆ＭＤＡ外，其它相应指标均有减低（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１）。结论：脂质过氧化和中分子物质参与油酸肺损伤的发病，山莨菪碱和肠道吸附剂对兔油酸肺损伤有防治作用。
OBJECTIVE: To investigate the effects of lipid peroxidation and middle molecular substances in experimental acute oleic acid-induced lung injury in rabbits and the preventive and therapeutic effects of anisodamine and intestinal adsorbent on oleic acid-induced lung injury. Methods: Eighteen rabbits were injected with oleic acid 0.1 m l / kg body weight to form acute lung injury model. 10 of them were treated with 10 mg / kg body weight of anisodamine and 1 g / kg body weight of intestinal adsorbent Treatment (each 5) as the treatment group, and the other 8 as the experimental group. Results: The activity of glutathione peroxidase (GSH-Px) in whole blood superoxide dismutase (SOD) and bronchoalveolar lavage fluid (BALF) was significantly decreased in oleic acid group compared with saline control group (P <0.05 and P <0.01). Malondialdehyde (MDA) and malondialdehyde (MDA) and lipid content (MDA / Lipid) in plasma and BALF were significantly increased (P <0.05-0.01) ; ALP, ALB and pulmonary coefficient in BALF were significantly increased (P <0.01); MMS in plasma and BALF also increased significantly (P <0.01). Compared with the oleic acid group, the activities of SOD and GSH-Px in both the anisodamine group and the intestinal adsorbent group were significantly increased (P <0.05-0.01). In addition to the plasma MDA, the corresponding indexes were decreased P <0.05 or P <0.01). CONCLUSION: Lipid peroxidation and the participation of middle molecular substances are involved in the pathogenesis of oleic acid-induced lung injury. Anisodamine and gut absorbents may have protective effects against oleic acid-induced lung injury in rabbits.