血管紧张素Ⅰ转换酶基因插入或缺失(ACE I/D)多态性与血管紧张素Ⅱ1型受体1166A/C基因(AT1R 1166A/C)多态性对川崎病(KD)患者局部缺血性心脏病可能的协同影响

• 作 者: Fukazawa R. Sonobe T. 虎小毅
• 机 构: Fukazawa R. Sonobe T. Hamamoto K.et al.Dr.Nippon Medical SchoolDepartment of Pediatrics,1-1-5 Sendag
• 出 处: 世界核心医学期刊文摘(儿科学分册)
• 发表日期: 2005年02期
• 关键词: 多态性 川崎病 基因插入 缺血性心脏病 血管紧张素Ⅱ 冠脉疾病 冠状动脉狭窄 血管紧张素Ⅰ 动脉狭窄 缺失

一般认为ACEI/D和AT1R1166A/C多态性是影响冠脉疾病发展的个体危险因素。作者试图寻找证据证明ACEI/D和AT1R1166A/C多态性对KD患者冠状动脉狭窄的影响。检测了147例健康对照者及281例日

It is generally believed that ACEI / D and AT1R1166A / C polymorphisms are individual risk factors affecting the development of coronary artery disease. The authors sought to find evidence to demonstrate the impact of ACEI / D and AT1R1166A / C polymorphisms on coronary artery stenosis in patients with KD. 147 healthy controls and 281 controls were tested