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Bliss法(又名机率单位法或加权回归法)把反应率转化为机率单位并予数学纠正,再加权重处理,然后直线回归求出校正线方法。此法立论严谨、结果可靠,被公认是求ED50(包括LD50)的最佳方法。即使是初学者计算出的半数效量差异也不大;但由于计算步骤繁复,过去用对数表协助手算需时两天,而且易出差错,Litchfield and Wilcoxon(1949)根据Bliss法原理,直接在对数机率纸上绘出回归直线,并用图表简化运算过程,深受药理学毒理学工作者的欢迎,但该法未经数学纠正和加权回归,求出的半数效量往往取决于作图者的熟练程度与主观倾
Bliss method (also known as probability unit method or weighted regression method) to convert the reaction rate into probability units and to mathematical correction, and then weighted processing, and then recalculate linear regression method. Rigorous rigorous legislation, the results are reliable, is recognized as the ED50 (including LD50) the best way. Even for beginners, the half-effect difference is not large. However, due to the complicated calculation steps, two days were used to assist the hand-counting when using logarithms, and errors were easily made. According to Bliss’s law, Litchfield and Wilcoxon (1949) Drawing regression lines directly on logarithmic probability paper and graphically simplifying the process is well received by pharmacologists and toxicologists, but the mathematical half-efficacy usually determined by the law without mathematical correction and weighted regression Figure proficiency and subjective dumping