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目的:探讨奥曲肽局部注射对DA大鼠类风湿性关节炎(RA)的疗效。方法:DA大鼠尾根部皮内一次性注射降植烷300μl建立RA模型,成模后连续4周每周1次足底注射奥曲肽0.005 mol.L-1,观察其对DA大鼠RA的疗效。结果:使用奥曲肽后,DA大鼠四肢掌指关节、指间关节以及踝关节红肿减轻,爪容积减小,关节活动度提高,机械缩爪阈值提高。结论:局部注射奥曲肽对DA大鼠RA具有较好的治疗作用,能够不同程度地缓解关节疼痛,改善关节功能。
Objective: To investigate the curative effect of octreotide local injection on rheumatoid arthritis (RA) in DA rats. Methods: RA model was established by intradermal injection of 300μl of propranolol into the tail root of DA rats. The rats were anesthetized with octreotide 0.005 mol·L-1 once a week for 4 weeks. . RESULTS: After using octreotide, the DA rats had reduced limbal metacarpophalangeal and interphalangeal joints and ankle swelling, reduced paw volume, increased joint mobility, and increased mechanical paw withdrawal threshold. CONCLUSION: Topical injection of octreotide has a good therapeutic effect on RA rats and can relieve joint pain and improve joint function to different extents.