中成药中无机元素标准制订方法的研究

• 作 者: 张奇凤 丁树良 范玫玫 辛锐铭 康海宁 曾列丹 罗芬
• 机 构: 南昌大学应用化学研究所,江西师范大学计算机科学技术学院,江西省药物研究所,江西师范大学计算机科学技术学院,南昌大学应用化学研究所,南昌大学应用化学研究所,江西师范大学计算机科学技术学院 南昌 3300
• 出 处: 中国新药杂志
• 发表日期: 2004年07期
• 关键词: 中成药 无机元素 限量标准

目的:获得中成药中无机元素的限量标准。方法:采用对应分析法对乌鸡白凤丸等中成药中的4种无机元素(Cu,Zn,Co,Fe)的化学分析数据进行聚类,并用人工神经网络法进行验证。结果:应用此2种方法均可将种类不同的中成药明显分开,并找出根据无机元素所分类作为研究对象的乌鸡白凤丸样本,用区间估计法获得了乌鸡白凤丸中Cu,Zn,Co,Fe 4种无机元素的限量标准。结论:对应分析法和人工神经网络法用于中成药的分类和区间估计法用于中成药的限量标准制订是可行的。

Objective: To obtain the limited standard of inorganic elements in Chinese patent medicines. Methods: The chemical analysis data of four kinds of inorganic elements (Cu, Zn, Co, and Fe) in Wuji Baifeng Pills etc. were clustered by the corresponding analysis method and verified by artificial neural network method. Results: Using these two methods can clearly separate the different types of proprietary Chinese medicines, and to find out the Wuji Baifeng Pills samples classified according to the inorganic elements as the research object, and use the interval estimation method to obtain the Cu, Zn in Wuji Baifeng Pills. , Co, Fe 4 kinds of inorganic elements of the limited standard. Conclusion: It is feasible to use the corresponding analysis method and artificial neural network method for the classification of Chinese patent medicines and the interval estimation method for the formulation of the limited standard of proprietary Chinese medicines.