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Objective: To summarize clinical experience of Professor QIAO Bao-zhang in treatment for pancreatic cancer, and to provide reference for clinicians. Methods: Through learning from Professor QIAO during his clinical practice and listening to his lectures, Professor QIAO Bao-zhang’s clinically proved cases of treating pancreatic cancer based on syndrome differentiation were organized and summarized. From aspects like etiology, pathogenesis, treatment principles and treatment methods of pancreatic cancer, Professor QIAO’s experience in diagnosis and treatment for this disease was analyzed and explored, and characteristics of medication were summarized. Two typical cases were selected as proof, and his treatment ideas and methods were explored. Results: Professor QIAO believes that the pathogenesis is mostly deficiency of vital Qi (正气), and stagnation of phlegm, heat and dampness in Zang-Fu (脏腑) and meridians. Around intermingled deficiency and excess, syndrome differentiation and treatment were performed. Due to treatment methods such as strengthening vital Qi to eliminate pathogenic factor, clearing heat, eliminating dampness and resolving phlegm, as well as removing toxicity and resolving hard mass, progress of malignant tumors was inhibited and recurrence and metastasis of malignant tumors were delayed. Conclusion: Professor QIAO’s experience in treating pancreatic cancer is worth learning.