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采用正常血糖高胰岛素钳夹技术测定２０例初诊非胰岛素依赖型糖尿病病人及８例正常人胰岛素敏感性高低，并测定血脂水平。两组的胰岛素敏感性指数分别为５．４５±３．０１Ｖｓ１１．４±２．９（Ｐ＜０．０１）；ＴＧ值分别为１．６９±０．４１Ｖｓ１．１９±０．２６ｍｍｏｌ·Ｌ－１（Ｐ＜０．０５）；ＨＤＬ－ｃｈ分别为１．２９±０．２４Ｖｓ１．６５±０．３１ｍｍｏｌ·Ｌ－１（Ｐ＜０．０５）。胰岛素敏感性下降是Ⅱ型糖尿病的一个特征，高ＴＧ、低ＨＤＬ－ｃｈ、血胰岛素浓度升高是胰岛素抵抗综合征的组成部分。
The insulin sensitivity of 20 newly diagnosed non-insulin-dependent diabetic patients and 8 normal controls were determined by the normal glucose hyperinsulinemic clamp technique. The levels of serum lipids were measured. The insulin sensitivity index of the two groups were 5.4 ± 3.01 VS 11.4 ± 2.9 (P <0.01), TG values were 1.69 ± 0.41 Vs1.19 ± 0.26 mmol·L- 1 (P <0.05), HDL-ch were 1.29 ± 0.24Vs1.65 ± 0.31mmol·L-1 respectively (P <0.05). Decreased insulin sensitivity is a characteristic of type 2 diabetes. High TG, low HDL-ch, and elevated serum insulin levels are part of the insulin resistance syndrome.