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目的评价替加环素的体外抗菌作用。方法采用微量肉汤稀释法测定替加环素对从北京协和医院临床分离200株菌的最低抑菌浓度(MIC),并与有关抗菌药物进行比较;数据分析采用WHONET-5.4软件。结果对临床分离的200株菌的MIC测定结果显示,替加环素、万古霉素、利奈唑烷对MRSA有高度的抗菌活性;1株耐万古霉素屎肠球菌对替加环素和利奈唑烷均敏感;所测抗菌药物中,替加环素对耐青霉素肺炎链球菌的MIC90值为0.064 mg/L,对鲍氏不动杆菌的MIC90值为2 mg/L,对产ESBL的12株大肠埃希菌和5株肺炎克雷伯菌敏感,对铜绿假单胞菌的MIC90值为32 mg/L。结论替加环素对与感染有关的常见需氧革兰阳性球菌和革兰阴性杆菌有很好的广谱抗菌活性,对铜绿假单胞菌的抗菌活性较低。
Objective To evaluate the in vitro antibacterial effect of tigecycline. Methods The minimum inhibitory concentration (MIC) of tigecycline in 200 clinical isolates from Peking Union Medical College Hospital was determined by the broth microdilution method and compared with the antibacterials. The data were analyzed by WHONET-5.4 software. Results The results of MIC determination of 200 clinically isolated strains showed that tigecycline, vancomycin and linezolid had a high antibacterial activity against MRSA. One strain of vancomycin-resistant Enterococcus faecium was resistant to tigecycline and linac Among the tested antibacterials, the MIC90 value of tigecycline against penicillin-resistant Streptococcus pneumoniae was 0.064 mg / L, and the MIC90 value against Acinetobacter baumannii was 2 mg / L, and that of ESBL-producing 12 Strain of E. coli was sensitive to 5 strains of Klebsiella pneumoniae and MIC90 of Pseudomonas aeruginosa was 32 mg / L. Conclusion Tigecycline has good broad-spectrum antibacterial activity against common aerobic Gram-positive cocci and Gram-negative bacilli related to infection, and has low antibacterial activity against Pseudomonas aeruginosa.