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目的：旨在探讨血浆ＰＡＩ－１活性与脑梗塞发病的关系。方法：利用发色底物法测定急性脑梗塞组和正常对照组的血浆ＰＡＩ－１活性。结果：实验结果显示急性脑梗塞组血浆ＰＡＩ－１活性较对照组明显增高，尤其脑梗塞急性后期血浆ＰＡＩ－１活性明显增高，而再次脑梗塞组血浆ＰＡＩ－１活性明显高于首次脑梗塞组。结论：血浆ＰＡＩ－１活性增高是脑梗塞发病的一个主要的危险因素，在脑梗塞的防治工作中应考虑到血浆ＰＡＩ－１活性的改变
Objective: To investigate the relationship between plasma PAI-1 activity and the incidence of cerebral infarction. Methods: Plasma PAI-1 activity in acute cerebral infarction group and normal control group was measured by chromogenic substrate method. Results: The results showed that plasma PAI-1 activity in acute cerebral infarction group was significantly higher than that in control group, especially PAI-1 activity in acute phase of acute cerebral infarction, PAI-1 activity in recurrent cerebral infarction group was significantly higher than that in first cerebral infarction group . CONCLUSION: Increased plasma PAI-1 activity is a major risk factor for the development of cerebral infarction. Changes in plasma PAI-1 activity should be considered in the prevention and treatment of cerebral infarction