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纤维连接蛋白(fibronectin Fn)主要分布于肾小球系膜。但在IgA肾病(IgAN)肾小球内,Fn的分布可变化为系膜型和毛细血管型两种,这种差别的意义尚未明了。我们对此进行了探讨。 一、对象与方法 随机选择107例IgAN的患者,常规取肾组织,行光镜、免疫病理及电镜检查。同时取血,尿标本检测。按Fn分布将病人分为:M组,Fn主要聚积于系膜区。B组,除系膜外,Fn在毛细血管攀亦明显沉积。病理分级:参考Lee氏标准[Human Pathol,1982,13:314],按系膜增生及肾小球硬化程度分为5级。临床分组:按入院时病人表现分类为(1)孤立血尿;(2)复发性血尿;(3)尿检异常;(4)肾炎综合征;(5)肾
Fibronectin Fn is mainly distributed in the mesangial. However, in IgA nephropathy (IgAN) glomerular, Fn distribution can be changed to mesangial and capillary type two, the significance of this difference is not yet clear. We have discussed this. First, the object and method A random selection of 107 cases of patients with IgAN, routine renal tissue, line light microscopy, immunopathology and electron microscopy. At the same time take blood, urine specimens tested. Fn distribution according to the patient is divided into: M group, Fn mainly in the mesangial area. Group B, in addition to mesangium, Fn in the capillary climbing also significantly deposited. Pathological grade: Reference Lee’s standard [Human Pathol, 1982,13: 314], according to the degree of mesangial proliferation and glomerular sclerosis is divided into five levels. CLINICAL CLASSIFICATION: Patients were classified as (1) isolated hematuria by admission; (2) recurrent hematuria; (3) abnormal urinalysis; (4) nephritic syndrome;