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真核细胞核转录因子Rel/NF-кB家族广泛调控着自昆虫至人类的免疫和炎症反应中一系列基因的表达。静息状态下,NF-кB二聚体与抑制性蛋白IкB结合而存在于胞质中。当细胞受外源性刺激时,NF-кB活化进入核内发挥其功能。目前,外源性信号活化NF-кB的机制已初步阐明,Rel/NF-кB/IкB/IKK信号转导途径在蛋白质水平的相互调控,以及在肿瘤发生中的意义的研究也已获得一定进展。本文综述了近年来Rel/NF-кB/IкB/IKK信号转导途径的分子机制及其与肿瘤发病关系的研究进展。
The Rel / NF-кB family of eukaryotic nuclear transcription factors extensively regulates the expression of a series of genes in immune and inflammatory responses from insects to humans. At rest, NF-кB dimers bind to the inhibitory protein IкB and are found in the cytoplasm. When cells are exogenously stimulated, NF-кB activates into the nucleus to exert its function. At present, the mechanism of exogenous signal activation NF-кB has been initially clarified, Rel-NF-кB / IкB / IKK signal transduction pathway at the protein level of mutual regulation, and the significance of tumorigenesis has also made some progress . This review summarizes the molecular mechanism of Rel / NF-кB / IкB / IKK signal transduction pathway and its relationship with tumor progression in recent years.