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目的 :研究川芎嗪、肝素治疗新生儿硬肿症的临床疗效。方法 :对 10 5例新生儿硬肿症随机分成对照组 53例 ,给予综合疗法 :观察组 52例 ,在综合疗法的基础上给予川芎嗪 ,对中、重度硬肿症加用肝素。结果 :观察组与对照组复温时间 ( h)分别为 11.6± 3.5,2 0 .0 9± 4 .3;平均硬肿消退时间 ( d)为 2 .70± 1.68,4 .50± 1.98;平均住院日数 11.38± 3.17,14.86± 3.5;显效率 4 8.0 8% ,2 2 .64% ;死亡率 1.92 % ,5.66% ;经统计学处理 P值均 <0 .0 1。结论 :观察组复温时间、硬肿消退时间、住院日数较对照组明显缩短 ,显效率明显高于对照组 ,死亡率明显低于对照组。
Objective: To study the clinical efficacy of ligustrazine and heparin in the treatment of neonatal sclerema. Methods: A total of 105 neonates with sclerema were randomly divided into control group (n = 53) and general therapy group (n = 52). TMP was given on the basis of comprehensive therapy and heparin was used on moderate and severe scleredema. Results: The rewarming time (h) in the observation group and the control group were 11.6 ± 3.5, 2.09 ± 4. 3, respectively; the mean dilatation time (d) was 2.70 ± 1.68 and 4.50 ± 1.98; The average length of stay was 11.38 ± 3.17 and 14.86 ± 3.5 respectively. The effective rates were 8.08% and 22.6% respectively. The mortality rates were 1.92% and 5.66% respectively. The P values were all <0.01. Conclusion: The rewarming time, sclerema regression time and hospitalization days in the observation group were significantly shorter than those in the control group. The effective rates were significantly higher in the observation group than those in the control group, and the mortality rate was significantly lower than that in the control group.