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本文就近年来前列腺素(PGS)在消化性溃疡病(PUD)发生中的作用研究近况介绍如下。一、PGS 对胃粘膜的细胞保护作用早在60年代未,Robert 曾发现动物及人的胃液内存在PGS,随后的研究表明消化道粘膜上皮细胞不断合成和分泌PGS。胃粘膜细胞主要合成分泌PGE 簇,其受迷走神经的兴奋性和胃泌素的调节。PGS 通过细胞保护作用而呈现出抗溃疡的作用。PGS 的细胞保护作用并不依赖于抑制胃
In this paper, in recent years prostaglandin (PGS) in the pathogenesis of peptic ulcer disease (PUD) research status introduced below. First, PGS on the gastric mucosal cytoprotection as early as the 60s, Robert has found that animal and human gastric juice PGS, subsequent studies have shown that gastrointestinal mucosal epithelial cells continue to synthesize and secretion of PGS. Gastric mucosal cells mainly synthesize and secrete PGE clusters, which are regulated by excitability of vagus nerve and gastrin. PGS shows anti-ulcer effect by cytoprotection. The cytoprotective effect of PGS does not depend on suppressing the stomach