论文部分内容阅读
本文报道应用多种多克隆B细胞激活剂(PBA)对31例法国慢性淋巴细胞白血病患者进行染色体检查的结果。其中25例(80％)获得成功。R带分析揭示13例核型正常,12例有克隆性核型异常(48％),其中2例沙及3号染色体,4例涉及11号染色体,3例涉及12号染色体(其中2例有“+12”)。核型异常检出的机会以晚期病例为高。作者还发现TPA是本组采用的PBA中最有效的一种,它具有培养成功率高(80％)、分裂相产量多和异常核型检出率大(31.8％)等优点。
This article reports the results of chromosomal testing of 31 patients with chronic lymphocytic leukemia in France using various polyclonal B cell activators (PBA). Twenty-five of them (80%) were successful. R-band analysis revealed 13 normal karyotypes and 12 clonal karyotype abnormalities (48%), of which 2 were sand and 3 chromosomes, 4 were related to chromosome 11 and 3 were related to chromosome 12 (2 of them had “+12”). Karyotype detection of abnormal opportunities for advanced cases as high. The authors also found that TPA is one of the most effective PBA used in this study. It has many advantages such as high success rate (80%), high yield of schizophrenia and high rate of abnormal karyotype (31.8%).