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目的：研究氟氧头孢注射剂在健康人体内的药代动力学。方法：8名健康志愿者单剂量静脉滴注氟氧头孢1g ，采用高效液相色谱（HPLC）法测定血浆和尿中药物浓度。结果：滴注完成即刻浓度（Cmax）为（56．15±13．16）μg／ml，末端相消除半衰期（t1／2β）为（1．29±0．32）h，分布容积（Vc）为（13．11±2.06）L，清除率（Cls）为（16．02±1.88）L／h，AUC为（64．86±4．93）μg·h／ml。结论：氟氧头孢体内过程符合二室开放模型，主要以原形经肾脏排出体外，8h累积尿排百分率为（79．39±4．01）％。
Objective: To study the pharmacokinetics of fluorooxy cephalosporin injection in healthy volunteers. Methods: Eight healthy volunteers were given a single intravenous infusion of 1 g fluorooxygenthosporide and the plasma and urinary drug concentrations were determined by high performance liquid chromatography (HPLC). Results: The Cmax was (56.15 ± 13.16) μg / ml and the terminal elimination half-life (t1 / 2β) was (1.29 ± 0.32) h. The volume of distribution (Vc) (13.11 ± 2.06) L, the clearance rate (Cls) was (16.02 ± 1.88) L / h and the AUC was (64.86 ± 4.93) μg · h / ml. CONCLUSION: The process of Fluorooxycytos in vivo is in accordance with the two-compartment open model, which is mainly excreted in the shape of kidney by the kidney. The cumulative urinary excretion rate at 8h is (79.39 ± 4.01)%.