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目的探讨肠易激综合症患者抑郁焦虑状况及其心理社会影响因素。方法应用一般资料调查表、抑郁自评量表(SDS)、焦虑自评量表(SAS)、艾森克人格问卷简式量表(EPQ-RSC)、生活事件量表(LSE)、社会支持量表(SSRS)、简易应对方式问卷(SCSQ)、自我效能感(GSES)对102例肠易激综合征患者(IBS组)和98例健康中年人(对照组)进行调查。结果 IBS组抑郁、焦虑发生率均高于正常对照组(<0.01)；IBS组的SDS得分、SAS得分显著高于对照组(<0.01)；IBS组的神经质人格、精神质人格、负性生活事件、消极应对方式得分均高于对照组，IBS组的内外向、掩饰程度、正性生活事件、社会支持、积极应对、自我效能得分均低于对照组(<0.05)；IBS组SDS得分的相关影响因素的多重线性回归分析显示内外向、神经质、负性生活事件、积极应对、自我效能感的得分有统计学意义(<0.05)；IBS组SAS得分的相关因素的多重线性回归分析显示内外向、神经质、负性生活事件、积极应对、社会支持、自我效能感的得分有统计学意义(<0.05)。结论 IBS患者抑郁、焦虑程度高于健康成人；IBS患者抑郁焦虑情绪与偏内向、神经质人格、经历较多负性生活事件、缺乏积极应对方式、自我效能感低均密切相关；IBS患者焦虑情绪还与缺乏社会支持密切相关。“,”Objective To investigate the depression and anxiety in patients with irritable bowel syndrome and their psychosocial factors. Methods General data questionnaire, Self rating Depression Scale (SDS), Self Rating Anxiety Scale (SAS), Eysenck Personality Questionnaire (EPQ-RSC), Life Event Scale (LSE), Social Support Rating Scale (SSRS), Simple Coping Style Questionnaire (SCSQ), General Self-Efficacy Scale (GSES) were investigated in 102 patients with irritable bowel syndrome (IBS group) and 98 healthy young people (control group). Results Incidence of anxiety and depression in the IBS group was significantly higher than the control group (P<0.01);The SDS and SAS scores of the IBS group were higher than the control group( <0.01);Scores on the dimension of neuroticism and psychoticism, and scores on the negative life events, negative coping style in the IBS group were higher than the control group. Scores on the dimension of introversion-extraversionin and deception, and scores on the positive life events, social support, positive coping, self-efficacy in the IBS group were lower than the control group ( <0.05); Multiple linear regression analysis of SDS score in IBS group showed that the score of internal and introversion-extraversionin, neuroticism, negative life events, positive coping, self-efficacy were statistically significant ( <0.05); Multiple linear regression analysis of SAS score in IBS group showed that the score of introversion-extraversionin and neuroticism, negative life events, positive coping, social support, self-efficacy were statistically significant ( <0.05). Conclusion Depression and anxiety in IBS patients were significantly higher than those in healthy adults. The depression and anxiety in patients with IBS were closely related to partial introverted personality, neurotic personality, negative life events, lack of positive coping style and self-efficacy. The anxiety in patients with IBS were closely related to social support, too.