【摘 要】
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BACKGROUND AND OBJECTIVESome studies have estimated that more than half of patients with diabetes mellitus have arthritis, and may eventually need a hip or a knee replacement. As several studies have
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BACKGROUND AND OBJECTIVESome studies have estimated that more than half of patients with diabetes mellitus have arthritis, and may eventually need a hip or a knee replacement. As several studies have demonstrated that hyperglycemia can adversely affect wound healing, the risk of poor outcomes among diabetics undergoing joint replacement is a concern. This meta-analysis was undertaken to clarify the prevalence of diabetes mellitus among patients undergoing primary total knee replacement, and to determine whether this disease impacts outcome.
METHODSA systematic search was conducted for publications between 1996 and 2014. That search yielded 14, high-quality, controlled observational studies covering 835, 071 total knee arthroplasties.
RESULTSThe data revealed that patients with diabetes mellitus were at increased risk of deep infection [odds ratio (OR)=1.61], periprosthetic fracture (OR=1.89), aseptic loosening (OR=9.36) and worse Knee Society Function subscores (mean difference=-5.86) relative to those without diabetes.
CONCLUSIONThis meta-analysis of studies concerning the effect of diabetes on the outcome of knee replacement found that diabetes increases the risk of infection, fracture, hardware loosening and poor outcome.
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