论文部分内容阅读
硬脂酰酪氨酸（ST）是一种稳定的低分子量物质。其免疫刺激性很小,是一种缓慢释放的不溶性载体,是铝佐剂的有机取代物。 作者用6周龄雌性Balb/c或杂系cFl小鼠,以重组乙型肝炎表面抗原（HBsAg）,破伤风类毒素（TT）,白喉类毒素,A群脑膜炎球菌多糖与TT的复合物（GAMP-TT）,人 类免疫缺陷症病毒（HIV）多肽以及三价脊髓灰质炎灭活疫苗等为抗原,对ST及其酯类似物进行了佐剂效果的观察（免疫程序为0、21天免疫、14、35和62天采血检测抗体）。 结果发现,在HBsAg组,ST及其酯类似物在初次免疫后14天所产生的抗体应答都高于铝,其中硬脂酰羟苯基甘氨酸和硬脂酰甘氨酰甘氨酸又明显高于ST。抗体应答同型分析表明,与铝一样,IgGl的增加最为明显,
Stearyl tyrosine (ST) is a stable low molecular weight substance. Its immunostimulant is small, is a slow release of insoluble carrier, is an aluminum adjuvant organic substitutes. The authors used six-week-old female Balb / c or miscellaneous cFl mice to reconstitute hepatitis B surface antigen (HBsAg), tetanus toxoid (TT), diphtheria toxoid, complex of meningococcal group A and TT (GAMP-TT), human immunodeficiency virus (HIV) polypeptide, trivalent poliovirus inactivated vaccine and the like were used as antigens to observe the adjuvant effect of ST and its ester analogues (the immunization procedure was 0, 21 days Immune, 14, 35, and 62 days blood collection detection antibody). The results showed that in the HBsAg group, the antibody response of ST and its ester analogue 14 days after the first immunization was higher than that of aluminum, and stearoyl hydroxyphenylglycine and stearoyl glycylglycine were significantly higher than that of ST . Antibody response Homology analysis showed that, like aluminum, IgGl increased most significantly,