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1例79岁女性患者因医院获得性肺炎给予莫西沙星400 mg,1次/d静脉滴注。当晚患者出现自言自语、焦虑,血压135/85 mm Hg(1 mm Hg=0.133 kPa)。医嘱维持抗感染治疗。此后患者精神症状加重,表现为不认识家人、应答不切题、幻觉、狂躁不安等。应用莫西沙星5 d后血压升至190/110 mm Hg,体温39.6℃,脑电图无异常。停用莫西沙星,改用美罗培南0.5 g,1次/8 h静脉滴注;并给予厄贝沙坦控制血压。2 d后患者精神症状缓解,血压、体温恢复正常。2周后随访,出院后未再应用厄贝沙坦,血压基本正常,未再出现精神症状。
One 79-year-old female patient was given moxifloxacin 400 mg once daily for hospital-acquired pneumonia. Patients complained that night, anxiety, blood pressure 135/85 mm Hg (1 mm Hg = 0.133 kPa). Medical advice to maintain anti-infective treatment. Since then the patient’s psychiatric symptoms worsened, manifested as do not recognize the family, answering the question, hallucinations, mania unease. After 5 days of application of moxifloxacin blood pressure rose to 190/110 mm Hg, body temperature 39.6 ℃, EEG no abnormalities. Moxifloxacin deactivated, use Meropenem 0.5 g, 1/8 h intravenous infusion; and given irbesartan to control blood pressure. Psychiatric symptoms relieved after 2 days, blood pressure, body temperature returned to normal. After 2 weeks of follow-up, irbesartan was not applied after discharge. The blood pressure was normal and no psychiatric symptoms occurred.