消炎痛关闭早产儿未闭动脉导管的临床观察(附7例报告)

• 作 者: 周爱卿 刘薇廷
• 机 构: 上海第二医学院附属新华儿童医院,上海市儿科研究所
• 出 处: 临床儿科杂志
• 发表日期: 1984年02期
• 关键词: 早产儿 消炎痛 动脉导管 少尿 鼻管 并发症 指征 临床观察 肾功能 动脉导管开放

本文报告应用前列腺素合成酶抑制剂——消炎痛关闭早产儿未闭的动脉导管,采用的药量为0.2mg/kg/次,每8小时一次,经鼻管给药,每例平均总量为0.48mg/kg。7例动脉导管未闭的早产儿中,5例关闭,导管关闭率为71.5%。主要的并发症为暂时性肾功能障碍,2例有暂时性少尿,1例有暂时性尿素氮增高。作者认为本文所采用的消炎痛剂量是有效、安全的。同时还讨论了消炎痛应用的指征、反指征、作用及并发症等。

This article reports the application of prostaglandin synthase inhibitor - indomethacin closed patent ductus arteriosus in preterm children with a dose of 0.2mg / kg / time, once every 8 hours, nasal administration, the average total amount per patient 0.48 mg / kg. Of the 7 patients with patent ductus arteriosus, 5 were closed and the catheter closure rate was 71.5%. The main complications were transient renal dysfunction, 2 cases of transient oliguria, and 1 case of transient increase in urea nitrogen. The author believes that the indomethacin dose used in this article is effective and safe. Also discussed indomethacin indications, anti-indications, effects and complications.