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Angew.Chem.Int.Ed.2013,52,12377~12380手性杂环结构作为重要骨架广泛存在于生物碱及药物分子中,同时也是非常重要的有机合成中间体.因此,发展高效高立体选择性构建手性杂环化合物一直都是有机合成的热点研究领域.基于1,3-偶极子与合适的2π-亲偶极子间的1,3-偶极环加成反应是构建五元杂环化合物的最有效的方法之一.Pyrazolidinium ylides和azomethine ylides作为常见的三原子偶极子在构筑具有生理活性多种手性五元含氮杂环中有非常广泛的应用.然而不同叶立德间的交叉
Angew.Chem.Int.Ed.2013,52,12377 ~ 12380 Chiral heterocyclic structures are widely found in alkaloids and drug molecules as important skeletons and are also very important organic synthesis intermediates. Therefore, the development of high-efficiency and high-stereoselectivity The construction of chiral heterocyclic compounds has always been a hot research field in organic synthesis.Based on the 1,3-dipolar cycloaddition reaction between 1,3-dipole and the appropriate 2π-dipolar dipoles, Pyrazolidinium ylides and azomethine ylides as the common triatomic dipole have a very wide range of applications in the construction of physiologically active chiral 5-membered nitrogen-containing heterocyclic rings. However, Cross