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目的检测原发性高血压及合并左心室肥厚患者窦性心率震荡(HRT)情况,探讨HRT指标对原发性高血压患者心脏自主神经功能损害的价值。方法选择128例原发性高血压病患者,按照超声心动图检查结果分为左心室肥厚者68例(A组),左心室正常者60例(B组),另选择67例健康体检者为对照组(C组),3组均接受24 h动态心电图检查,计算3组的窦性HRT初始值(TO)及震荡斜率值(TS),比较3组间的差异。结果 A、B 2组与C组比较,TO值均明显增大,TS值则明显降低(P均<0.01),TO及TS异常发生率明显增高(P<0.01),与B组比较,A组TO值增大、TS值降低显著(P均<0.01),TO及TS异常发生率增高(P<0.05)。结论高血压病患者窦性HRT现象减弱,自主神经功能明显受损,左心室肥厚者损害更严重。
Objective To investigate the sinus rhythm of heart rate (HRT) in patients with essential hypertension and patients with left ventricular hypertrophy and to explore the value of HRT in the treatment of cardiac autonomic dysfunction in patients with essential hypertension. Methods A total of 128 patients with essential hypertension were divided into two groups according to echocardiography: 68 cases with left ventricular hypertrophy (group A), 60 cases with normal left ventricle (group B) and 67 cases with healthy subjects The control group (C group) and the three groups received 24 h Holter monitoring. The initial values of TOF and TS were calculated in three groups. The differences among the three groups were compared. Results Compared with group C, the TO and T values of group A and group B were significantly increased (P <0.01), and the abnormalities of TO and TS were significantly increased (P <0.01). Compared with group B, group A Group TO increased, TS value decreased significantly (P <0.01), TO and TS abnormalities increased (P <0.05). Conclusions The sinusoidal HRT in patients with essential hypertension is weakened, the function of autonomic nerve is obviously impaired, and the damage of left ventricular hypertrophy is more serious.