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目的探讨和分析醒脑静联合更昔洛韦治疗流行性腮腺炎合并脑炎的临床效果和安全性。方法选取2014年5月至2015年5月在我院接受治疗的流行性腮腺炎合并脑炎患儿102例,按照随机数字表法进行分析。结果随机分为3组:联合组(n=34)、醒脑静组(n=34)和更昔洛韦组(n=34)。对3组患儿均采取常规治疗;对联合组患儿在常规治疗基础上给予醒脑静联合更昔洛韦进行治疗,对醒脑静组患儿在常规治疗基础上给予醒脑静进行治疗,对更昔洛韦组患儿在常规治疗的基础上给予更昔洛韦进行治疗。比较3组患儿的治疗总有效率,在发热、头痛、呕吐、神经病理等临床症状的持续时间,及不良反应发生率。联合组患儿的治疗总有效率显著高于醒脑静组和更昔洛韦组(P<0.05),联合组患儿头痛、发热、呕吐和神经病理征的持续时间显著短于醒脑静组和更昔洛韦组(P<0.05),以上差异均有统计学意义。3组患儿均未发生严重的不良反应,其不良反应发生率差异无统计学意义(P>0.05)。结论对于流行性腮腺炎合并脑炎的患儿采取醒脑静联合更昔洛韦的治疗,效果显著,能显著缩短患儿的症状持续时间,并且安全可靠,值得推广应用。
Objective To investigate and analyze the clinical effects and safety of xingnaojing combined with ganciclovir in the treatment of mumps combined with encephalitis. Methods A total of 102 cases of mumps-associated encephalitis in our hospital from May 2014 to May 2015 were selected and analyzed according to random number table. The results were randomly divided into 3 groups: combination group (n = 34), Xingnaojing group (n = 34) and ganciclovir group (n = 34). On the basis of conventional treatment, the children in the combined group were given Xingnaojing combined with ganciclovir for treatment, and the Xingnaojing group was given Xingnaojing on the basis of routine treatment , The ganciclovir group was given ganciclovir on the basis of routine treatment. The total effective rate was compared between the three groups in the duration of clinical symptoms such as fever, headache, vomiting, neuropathology and the incidence of adverse reactions. The total effective rate of treatment group was significantly higher than that of Xingnaojing group and ganciclovir group (P <0.05). The duration of headache, fever, vomiting and neuropathology in the combined group was significantly shorter than that of Xingnaojing Group and ganciclovir group (P <0.05), the above differences were statistically significant. No serious adverse reactions occurred in all three groups, and the incidence of adverse reactions was not significantly different (P> 0.05). Conclusion The treatment of moxibustion combined with ganciclovir in children with mumps and encephalitis has significant effect, which can significantly shorten the duration of symptoms in children and is safe and reliable, which is worth popularizing and applying.