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目的:探讨免疫比浊法检测血清β2-微球蛋白在妊娠期高血压疾病诊断中的临床意义。方法:系统研究免疫比浊法检测血清β2-微球蛋白的精密度、回收率及干扰因素,并比较正常妊娠组和妊娠高血压组血清β2-微球蛋白水平。结果:免疫比浊法检测血清β2-微球蛋白批内平均变异系数为1.93%,批间为2.75%,平均回收率97.7%。血红蛋白(Hb)在1g/L以下、甘油三酯<6 mmol/L及维生素C≤0.5g/L时对免疫比浊法无干扰。妊娠高血压组血清β2-微球蛋白结果明显高于正常妊娠组,差异有统计学意义(P<0.05)。结论:免疫比浊法检测血清β2-微球蛋白灵敏度高、重复性好、抗干扰能力强,对妊娠期高血压时肾小球滤过功能损害有早期诊断价值。
Objective: To investigate the clinical significance of serum immunoglobulin β2-microglobulin in the diagnosis of hypertensive disorder complicating pregnancy. Methods: The precision, recovery rate and interference factors of serum β2-microglobulin were detected by immunoturbidimetry. The levels of serum β2-microglobulin in normal pregnancy and gestational hypertension were compared. Results: The mean coefficient of variation (CV) of serum β2-microglobulin in serum was 1.93% by immunoturbidimetry, 2.75% in batch and 97.7% in average. Hemoglobin (Hb) in 1g / L or less, triglyceride <6mmol / L and vitamin C ≤ 0.5g / L immune turbidimetric method without interference. Serum β2-microglobulin in pregnancy-induced hypertension group was significantly higher than that in normal pregnancy group (P <0.05). Conclusion: Immunoturbidimetry for the detection of serum β2-microglobulin has high sensitivity, good repeatability, strong anti-interference ability and early diagnosis of glomerular filtration dysfunction in hypertensive pregnancy.