论文部分内容阅读
本实验检测134例各期乙型肝炎、12例乙肝性肝硬化、15例无症状HBsAg携带者、10例SLE、11例非原发性肝癌的恶性肿瘤病人,以及42例健康成人血清标本的HBsAg、抗HBs、抗HBc和抗LSP以及循环免疫复合物。结果表明乙肝性肝硬化和慢活肝组的抗LSP阳性率和平均滴度较高,且与肝功能损伤程度呈平行关系。如果急肝病人的抗LSP出现早,滴度高和持续时间长,则容易转变成慢性持续性感染。实验还证明了LSP是一种具有肝病特异性和不完全性种系交叉反应的自身抗原。
The experiment detected 134 cases of hepatitis B, 12 cases of hepatitis B cirrhosis, 15 cases of asymptomatic HBsAg carriers, 10 cases of SLE, 11 cases of non-primary liver cancer and 42 cases of healthy adult serum samples HBsAg, anti-HBs, anti-HBc and anti-LSP as well as circulating immune complexes. The results showed that the positive rate of anti-LSP and the average titer of hepatitis B cirrhosis and chronic active liver group were higher, and had a parallel relationship with the degree of liver injury. If the anti-LSP of acute liver disease appear early, high titer and long duration, it is easy to change into chronic persistent infection. The experiment also proved that LSP is an autoantigen with cross-reaction of liver disease-specific and incomplete germ-line.