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本研究旨在回顾性评价行成功冠脉支架术后独用阿司匹林治疗与阿司匹林合用抵克力得(ticlopidine)治疗对冠脉支架内血栓形成率和临床事件发生率的影响。 方法 本研究包括801例行成功冠脉支架术的患者。成功冠脉支架术定义为:冠脉支架术后冠脉造影目测冠脉残余狭窄<10％。患者术后非随机予单独口服阿司匹林325mg/d长期治疗(ASA组,264例伴348处病变),或同时口服抵克力得250mg每天2次,连续1个月(TIC-ASA组,537例伴737处病变)。出院后随访1个月。主要临床事件包括死亡、紧急CABG、择期CABG、心肌梗塞(Q波或非Q波)、紧急重复介入治疗或血管并发症。急性血栓形成定义为:冠脉支架术后24小时内发生的冠脉闭塞即冠脉造影显示支架部位冠脉血流为0级。亚急性血栓形
The purpose of this study was to retrospectively evaluate the effect of ticlopidine combined with aspirin alone on the rate of coronary thrombosis and the incidence of clinical events after successful coronary stenting. Methods This study included 801 patients who underwent successful coronary stenting. Successful coronary stenting was defined as coronary residual stenosis <10% after coronary angiography. Patients were randomly assigned to aspirin 325 mg / d long-term treatment (ASA group, 264 patients with 348 lesions), or 250 mg orally twice daily for 1 month (TIC-ASA group, 537 patients With 737 lesions). Follow-up 1 month after discharge. The main clinical events include death, emergency CABG, elective CABG, myocardial infarction (Q wave or non-Q wave), emergency repeat intervention or vascular complications. Acute thrombosis was defined as a coronary occlusion or coronary angiography that occurred within 24 hours after coronary stenting showing grade 0 coronary stenting. Subacute thrombosis