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分析我院收治的9例有机氟中毒病例的发病特点、临床表现和救治过程。有机氟中毒主要损害呼吸系统,重者引起肺水肿甚至急性呼吸窘迫综合征(ARDS),也可累及心、肝等脏器。本组患者发病比较隐匿,出现咳嗽、气促后分散当地医院就诊,当时因毒物接触史不明,延误早期治疗,导致病情加重。9例患者胸部CT表现为弥漫性磨玻璃影,密度不均,部分融合成团片影,两肺较为对称,严重病例两肺下叶见大片实变影。血清总免疫球蛋白E(Ig E)升高7例,其中重度中毒者均升高,提示Ⅰ型超敏反应可能参与致病过程。以消除肺水肿为救治重点,采用早期、足量、短程大剂量激素冲击为主的综合治疗,预后较好。
Analysis of our hospital admitted 9 cases of organ fluorosis in the incidence of disease, clinical manifestations and treatment process. Organic fluoride poisoning mainly damage the respiratory system, severe cases cause pulmonary edema and even acute respiratory distress syndrome (ARDS), can also affect the heart, liver and other organs. The incidence of this group of patients more hidden, there cough, shortness of breath after the dispersion of the local hospital for treatment, when the contact was unknown because of poisoning, delay early treatment, leading to aggravating. Chest CT findings of 9 patients showed diffuse ground glass opacity, uneven density, partial fusion into pellets, symmetry between the two lungs, and severe cases with large solidified changes in the lower lobes of both lungs. Serum total immunoglobulin E (Ig E) increased in 7 cases, including severe poisoning were increased, suggesting that type Ⅰ hypersensitivity may be involved in the pathogenesis. To eliminate pulmonary edema as the focus of treatment, the use of early, adequate, short-term high-dose hormone-based comprehensive treatment, the prognosis is good.