论文部分内容阅读
目的分析2型糖尿病在降糖药口服控制不理想的情况下改用格列美脲联合甘精胰岛素治疗的临床效果,为临床治疗提供依据。方法选取95例2型糖尿病患者(之前均有口服降糖药),随机分成观察组和对照组,观察组使用格列美脲联合甘精胰岛素治疗方法,对照组使用低精蛋白胰岛素治疗方法,跟踪随访3个月观察各组疗效。结果两组患者的HbA1c(糖化血红蛋白),FPG(空腹血糖浓度),2hPG(饭后2 h血糖浓度)均有所下降;观察组中低血糖患者出现的比例显著低于对照组。结论格列美脲联合甘精胰岛素对使用降糖药口服控制不理想的2型糖尿病效果显著,且安全有效,具较高的临床价值,在治疗2型糖尿病时值得广泛使用。
Objective To analyze the clinical efficacy of glimepiride combined with insulin glargine in the treatment of type 2 diabetes under the condition of oral administration of hypoglycemic agents is not ideal, and provide the basis for clinical treatment. Methods Ninety-five patients with type 2 diabetes mellitus (previously oral hypoglycemic agents) were randomly divided into observation group and control group. The observation group was treated with glimepiride combined with insulin glargine, the control group was treated with hypoproteinemic insulin, Follow up for 3 months to observe the effect of each group. Results HbA1c, FPG and 2hPG in both groups decreased after 2 hours. The incidence of hypoglycemia in the observation group was significantly lower than that in the control group. Conclusion Glimepiride combined with insulin glargine has obvious effect on type 2 diabetes with oral administration of hypoglycemic agents which is not satisfactory. It is safe and effective and has high clinical value. It is widely used in the treatment of type 2 diabetes mellitus.