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本文对４２例重症肌无力（ＭＧ）患者及４０例正常对照外周血单个核细胞分必ＩＬ－１活性进行了检测，并对１４例ＭＧ患者在应用糖皮质激素（ＧＣ）一月后ＩＬ－１活性变化进行了观察。结果：ＭＧ患者ＩＬ活性明显高于正常对照，ＭＧ患者ＩＬ－１活性变化与ＡｃｈＲａｂ产生密切相关，与ＭＧ临床类型、病情、愈后密切相关，ＧＣ治疗后ＩＬ－１活性明显降低。结果提示ＩＬ－１参与了ＭＧ的发生、发展，检测ＩＬ－１活性对指导ＭＧ临床有重要的参考价值，ＧＣ可能通过抑制ＩＬ－１参与了ＭＧ的发生、发展，检测ＩＬ－１活性对指导ＭＧ临床有重要的参考价值，ＧＣ可能通过抑制ＩＬ－１活性而发挥其免疫治疗作用。
In this paper, 42 cases of myasthenia gravis (MG) and 40 cases of normal control peripheral blood mononuclear cells were detected IL-1 activity, and 14 cases of MG patients with glucocorticoid (GC) after a month of IL- 1 activity was observed. Results: The activity of IL in MG patients was significantly higher than that in normal controls. The changes of IL-1 activity in MG patients were closely related to the production of AchRab. The activity of IL-1 in MG patients was closely related to the clinical type, disease and prognosis of MG patients. The results suggest that IL-1 is involved in the genesis and development of MG. Detecting the activity of IL-1 may play an important role in guiding the clinical practice of MG. GC may be involved in the pathogenesis and development of MG by inhibiting IL-1. MG clinically important reference value, GC may play an immunotherapeutic effect by inhibiting IL-1 activity.