论文部分内容阅读
目的:对西宁地区(2 260m)慢性阻塞性肺疾病急性加重(AECOPD)合并呼吸衰竭患者早期给予双水平无创正压通气(NIPPV)治疗进行临床观察分析。方法:选取在我科自2009年1月—2012年1月住院确诊AECOPD合并呼吸衰竭患者100例,随机分为治疗组(50例)及对照组(50例),两组在常规治疗基础上,治疗组给予双水平无创正压通气治疗(NIPPV),观察两组治疗前、治疗2小时、治疗24小时、治疗7天的PaCO2、PaO2、HR、RR,并进行对比。结果:两组治疗前、后PaCO2、PaO2、RR及HR均有明显差异(P<0.05),治疗组及观察组治疗后PaCO2、PaO2、RR及HR亦有显著差异(P<0.05)、且住院天数明显缩短。结论:在西宁地区早期应用NIPPV治疗AECOPD合并呼吸衰竭能尽早使PaCO2下降、PaO2升高、RR及HR减低,缩短住院天数,降低死亡率,减轻患者经济负担,且无明显不良反应。
OBJECTIVE: To observe and analyze the early stage of noninvasive positive pressure ventilation (NIPPV) in patients with AECOPD complicated with respiratory failure in Xining region (2260m) with chronic obstructive pulmonary disease. Methods: A total of 100 AECOPD patients with respiratory failure diagnosed in our hospital from January 2009 to January 2012 were randomly divided into treatment group (50 cases) and control group (50 cases), and the two groups were treated on the basis of routine treatment The patients in the treatment group received double-level NIPPV. The PaCO2, PaO2, HR and RR of two groups before treatment, 2 hours after treatment, 24 hours after treatment and 7 days after treatment were observed and compared. Results: There were significant differences in PaCO2, PaO2, RR and HR between the two groups before and after treatment (P <0.05). There were also significant differences in PaCO2, PaO2, RR and HR after treatment between treatment group and observation group Hospitalization days were significantly shorter. Conclusion: The early treatment of AECOPD with respiratory failure in Xining district in early stage of NIPPV can decrease PaCO2, increase PaO2, reduce RR and HR, shorten hospital stay, reduce mortality, and reduce the economic burden of patients with no obvious adverse reactions.