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目的:探讨溃疡性结肠炎合并肿瘤性息肉的流行病学、发病机制的特点以及危险因素。方法:选择我院2008年6月至2012年3月收治的25例溃疡性结肠炎合并肿瘤性息肉(观察组)、25例散发性肿瘤性息肉(对照一组),25例大肠息肉癌变患者为研究对象(对照二组)的临床资料进行回顾性分析,对各组患者息肉标本及临床危险因素进行分析。结果:观察组结肠镜下形态学特点、组织学分型与对照一组存在显著性统计学差异(P<0.05),而与对照二组患者无统计学差异(P>0.05)。观察组与对照一组的临床危险因素比较,其中性别、年龄、BMI指数、病理分型、息肉直径大小、P53阳性和其他因素(有原发性硬化性胆管炎、结直肠癌家族史)存在统计学差异,与对照二组危险因素仅有性别存在统计学差异。结论:溃疡性结肠炎合并肿瘤性息肉患者在病理组织类型特点与危险因素与息肉癌变者更为相近,临床诊断治疗过程中应给予高度重视。
Objective: To investigate the epidemiology, pathogenesis and risk factors of ulcerative colitis with tumor polyps. Methods: Twenty-five patients with ulcerative colitis with tumor polyps (observation group), 25 patients with sporadic tumor polyps (control group) and 25 patients with colorectal polyposis cancer who were treated in our hospital from June 2008 to March 2012 were enrolled. The clinical data of the study group (control group two) were retrospectively analyzed, and the polyp specimens and clinical risk factors in each group were analyzed. Results: There was a significant difference between the observation group and the control group (P <0.05). There was no significant difference between the two groups (P> 0.05). The clinical risk factors in the observation group and the control group were compared. There were gender, age, BMI, pathological type, diameter of polyp, P53 positive and other factors (with primary sclerosing cholangitis and family history of colorectal cancer) Statistical differences, and the control group two risk factors only gender differences. Conclusion: Patients with ulcerative colitis and polypoid tumors are more similar in pathological type and risk factors than those with polypoid carcinomas, and should be given high priority in clinical diagnosis and treatment.