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目的:探讨卡维地洛治疗慢性心力衰竭短期疗效及对血浆N-端脑钠素前体(Nt-proBNP)的影响。方法:采用随机对照研究,将92例慢性心力衰竭患者随机分成卡维地洛组和对照组,2组疗程均为8周,2组患者均于给药前及给药后8周,观察临床疗效,超声心动图测定左心室射血分数(LVEF)、心排血量(CO)及心排指数(CI),用电化学发光免疫学方法及夹心法原理检测血浆Nt-proBNP浓度。结果:与给药前相比,对照组LVEF、CO和CI无显著变化,而卡维地洛组LVEF、CO和CI增加(P<0.05)。2组Nt-proBNP血浆浓度明显降低,但卡维地洛组与对照组比Nt-proBNP血浆浓度下降更明显(P<0.05)。结论:卡维地洛能够在短期改善心功能不全。而Nt-proBNP血浆浓度是一个反映心力衰竭严重程度、判断疗效的敏感指标,值得临床推广和应用。
Objective: To investigate the short-term curative effect of carvedilol on chronic heart failure and its effect on plasma N-terminal pro-brain natriuretic peptide (Nt-proBNP). Methods: A randomized controlled study of 92 patients with chronic heart failure were randomly divided into carvedilol group and control group, two courses of treatment were 8 weeks, two groups of patients before and after administration of 8 weeks, the clinical observation The left ventricular ejection fraction (LVEF), cardiac output (CO) and cardiac index (CI) were measured by echocardiography. Plasma Nt-proBNP concentration was measured by electrochemiluminescence immunoassay and sandwich method. RESULTS: There was no significant change in LVEF, CO and CI in the control group compared with those before administration, while LVEF, CO and CI increased in the carvedilol group (P <0.05). Plasma concentrations of Nt-proBNP were significantly decreased in both groups, but the plasma concentrations of Nt-proBNP were more significantly decreased in the carvedilol group compared with the control group (P <0.05). Conclusion: Carvedilol can improve cardiac insufficiency in the short term. The plasma Nt-proBNP concentration is a reflection of the severity of heart failure to determine the efficacy of sensitive indicators, worthy of clinical promotion and application.