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目的通过检测几种常见的风湿性疾病患者血中黏膜相关上皮趋化性细胞因子(CCL28)的水平变化,探讨其水平变化在风湿性疾病中的作用及其与临床相关指标的关系。方法采用酶联免疫吸附试验对系统性红斑狼疮、类风湿关节炎、干燥综合征、强直性脊柱炎患者及健康对照者血中的CCL28进行测定。结果风湿性疾病患者血中的CCL28明显高于健康对照者;风湿性疾病患者血中CCL28的水平变化与各种疾病活动性指标明显相关。结论 CCL28可能参与了风湿性疾病的发病过程,且在一定程度上反映疾病的严重程度,阻断CCL28及其受体的相互作用,可能成为风湿性疾病治疗的有效方法之一。
Objective To investigate the role of CCL28 in the blood of patients with rheumatic diseases and its relationship with clinically relevant indicators by detecting the changes of the blood levels of mucosal-associated epithelial chemotactic cytokines (CCL28) in several common rheumatic diseases. Methods The serum levels of CCL28 in patients with systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, ankylosing spondylitis and healthy controls were measured by enzyme linked immunosorbent assay. Results The serum CCL28 in patients with rheumatic diseases was significantly higher than that in healthy controls. The levels of CCL28 in patients with rheumatic diseases were significantly correlated with the activity of various diseases. Conclusion CCL28 may be involved in the pathogenesis of rheumatic diseases, and to a certain extent reflect the severity of the disease, blocking the interaction of CCL28 and its receptors may be one of the effective methods for the treatment of rheumatic diseases.