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体外试验发现一种磷硫寡去氧核着酸（25．merPS－oligonucleotide，GEM91）是I型人类免疫缺陷病毒（HIV．I）的强效抑制剂。使用多种不同分析体系已证实GEM91以25~流键对HIV-I起止基因互补抑制HIV－I复制。然而，关于GEM91在人体内的药物动力学及代谢变化所知甚微，作者对此进?
In vitro experiments found that a phosphorothioate oligodeoxynucleotide (25.merPS-oligonucleotide, GEM91) is a potent inhibitor of type I human immunodeficiency virus (HIV.I). Using a variety of different assay systems, it has been demonstrated that GEM91 inhibits HIV-I replication by HIV-I start-stop complementarity with a 25-fold linkage. However, little is known about the pharmacokinetics and metabolic changes of GEM91 in the human body.