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目的研究血尿酸与急性脑梗死的相关性。方法前瞻性地观察360例急性脑梗死患者与300例非梗死患者血尿酸水平及高尿酸血症(HUA)的发病率。根据血尿酸水平将梗死组患者,分为高尿酸血症组和血尿酸正常组,比较两组患者年龄、性别、体质量、血糖、血脂、血压等指标的差异。比较高尿酸血症组和血尿酸正常组急性脑梗死发病时及治疗后的神经功能缺失程度。结果 (1)梗死组患者的平均血尿酸水平、HUA发病率高于非梗死组。(2)高尿酸组患者的体质量、空腹血糖、血脂水平均高于血尿酸正常组。(3)急性脑梗死发病时高尿酸血症组患者神经功能缺失程度重,经治疗后恢复程度差于血尿酸正常组。结论高尿酸血症与急性脑梗死具有相关性。
Objective To study the correlation between serum uric acid and acute cerebral infarction. Methods The prospective study of 360 patients with acute cerebral infarction and 300 patients with non-infarction in patients with uric acid levels and the incidence of hyperuricemia (HUA). Patients in the infarction group were divided into hyperuricemia group and normal blood uric acid group according to the level of serum uric acid. The differences of age, sex, body weight, blood glucose, blood lipid and blood pressure were compared between the two groups. To compare the degree of neurological deficits in the patients with hyperuricemia and normal blood uric acid group after onset of acute cerebral infarction and after treatment. Results (1) The mean serum uric acid level and the incidence of HUA in patients with infarction were higher than those in non-infarcted patients. (2) The body mass, fasting blood glucose and blood lipids in hyperuricemia group were higher than those in normal group. (3) The onset of acute cerebral infarction patients with hyperuricemia severe neurological deficits, the degree of recovery after treatment is worse than the normal group of serum uric acid. Conclusion Hyperuricemia is associated with acute cerebral infarction.