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Psoriasis is a common inflammatory hyperproliferative skin disorder infiltrated predominantly by CD4-positive T-helper cells that produce pro-inflammatory cytokines such as interferon (IFN)-γ,tumor necrosis factor (TNF)-α,transforming growth factor (TGF)-β,and interleukin-17 [1,2].In recent years,mesenchymal stem cells (MSCs) derived from patients with psoriasis have gained attention.Orciani et al.[3] found that the resident dermal MSCs (DMSCs) produce angiogenic and pro-inflammatory mediators,which leads to a reduction in the antioxidant capacity and contributes to the development of skin lesions in psoriasis.Recently,we have investigated the biological properties of DMSCs in psoriasis (Supplementary Figs.S1-S3),and these studies revealed that abnormities were already present at the level of MSCs.In prior microarray,we also identified many inflammation-related candidate targets that were significantly differently expressed in psoriasis (the data were deposited under NCBI GEO GSE42632),such as early B-cell factor-3 (EBF3),neural cell adhesion molecule-1 (NCAM1),and protein kinase C zeta (PRKCZ) [4].