论文部分内容阅读
幽门螺杆菌(Hp)与胃癌的关系日益受到广泛关注,大量的流行病学研究发现Hp感染高发区的胃癌发病率显著高于Hp感染低发区;血清Hp特异性抗体阳性率胃癌患者显著高于非胃癌患者。因而WHO已将Hp列为Ⅰ类致癌物。然其致癌机制迄今尚未阐明。亚硝酸盐,N-亚硝胺(简称亚硝胺)均属强烈致癌物,特别是后者已广泛用于实验动物胃癌模型的建立。Hp是否能通过亚硝酸盐、亚硝胺途径致癌呢?至今国内
The relationship between Helicobacter pylori (Hp) and gastric cancer is receiving more and more attention. A large number of epidemiological studies have found that the incidence of gastric cancer in Hp-infected areas is significantly higher than that in Hp-infected areas. The positive rate of serum Hp-specific antibodies is significantly higher in patients with gastric cancer In non-gastric cancer patients. WHO has therefore classified Hp as a Class I carcinogen. However, its carcinogenic mechanism has not yet been clarified. Nitrite, N-nitrosamine (referred to as nitrosamines) are strong carcinogens, especially the latter has been widely used in experimental animal model of gastric cancer. Hp can nitrite, nitrosamines way carcinogenic it? Domestic