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对51例下丘脑—垂体疾病患者进行促甲状腺激素释放激素(TRH)试验,以观察不同病变时血清促甲状腺激素(TSH)对TRH试验的反应。结果显示51例病人中TRH试验反应异常的有27例,占52.9%,与正常对照组有非常显著性差异(P<0.005)。其中下丘脑病变者反应较为一致,多呈延迟反应;垂体病变者反应变化较大。在判定结果时应考虑病变的性质,部位,激素与激素或神经递质间的相互关系以及病程和患者的营养状况等因素的影响。
Thyroid-stimulating hormone releasing hormone (TRH) test was performed in 51 patients with hypothalamic-pituitary disease to observe the response of serum thyrotropin (TSH) to TRH in different pathological changes. The results showed that 51 cases of TRH test abnormal reaction in 27 cases, accounting for 52.9%, and the normal control group had a very significant difference (P <0.005). One of the hypothalamic lesions were more consistent response, mostly delayed response; pituitary lesions larger changes in response. In determining the outcome of the disease should be considered the nature of the site, hormones and hormones or neurotransmitters and the relationship between the duration and nutritional status of patients and other factors.