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目的探究女性2型糖尿病患者绝经后的骨密度变化及其与糖尿病的相关性。方法对76例绝经后女性2型糖尿病患者及80例健康的绝经女性用双能X射线吸收法行L2-4、Ward’s三角区、股骨颈、大转子骨密度测量,并测定糖尿病患者空腹血糖、空腹胰岛素、空腹C肽、糖基化血红蛋白等指标。结果①绝经后女性2型糖尿病患者L4、Ward’s三角区骨密度均较健康者显著降低(P<0.05)。②多元回归分析显示:女性糖尿病患者骨密度改变与糖尿病病程、糖基化血红蛋白及绝经年数是负相关(P<0.05),与体重指数呈正相关(P<0.05),与空腹血糖、胰岛素及C-肽等未见相关性。结论2型糖尿病女性患者绝经后骨密度降低较健康女性更为明显。糖尿病的病程和长期的高血糖对骨密度降低有一定作用。
Objective To investigate the changes of bone mineral density (BMD) in postmenopausal women with type 2 diabetes mellitus (T2DM) and its relationship with diabetes. Methods 76 cases of postmenopausal women with type 2 diabetes mellitus and 80 healthy menopausal women were measured by dual energy X-ray absorptiometry in L2-4, Ward’s triangle area, femoral neck and trochanter bone mineral density measurement, and determination of fasting blood glucose, Fasting insulin, fasting C-peptide, glycosylated hemoglobin and other indicators. Results ① The bone mineral density of L4 and Ward’s trigone in postmenopausal women with type 2 diabetes mellitus was significantly lower than that of healthy people (P <0.05). ②Multivariate regression analysis showed that the change of bone mineral density in women with diabetes was negatively correlated with the duration of diabetes, glycosylated hemoglobin and the number of menopause (P <0.05), positively correlated with body mass index (P <0.05), and with fasting blood glucose, insulin and C - Peptides and so no correlation. Conclusion The decrease of bone mineral density in postmenopausal women with type 2 diabetes is more obvious than in healthy women. The duration of diabetes and long-term hyperglycemia have a role in reducing bone mineral density.