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目的探讨醋酸烯诺孕酮(ST-1435)对妊娠大鼠的抗早孕活性。方法妊娠8d大鼠随机分为6组:阴性对照组给予生理盐水皮下注射,阳性对照组给予米非司酮灌胃,实验组给予不同剂量ST-1435皮下注射。各组于妊娠第14天处死,观察妊娠结局;并测定给药前后血清孕酮(P)与黄体生成素(LH)水平。结果单次注射16.0mg/kg剂量ST-1435的抗早孕率83.6%,与米非司酮12.0mg/kg分3次灌服的抗早孕率84.7%相似,与阴性对照组相比有显著性差异(P<0.05)。8.0和4.0mg/kgST-1435单次给药的抗早孕率分别为24.6%和11.7%。单次注射16.0或8.0mg/kgST-1435对妊娠大鼠血清LH和P有明显的抑制作用。结论单次注射16.0mg/kgST-1435有与米非司酮12.0mg/kg分3次灌服相似的抗早孕效果。但8.0和4.0mg/kg的ST-1435单次给药无明显的抗早孕效果。此外大剂量的ST-1435对妊娠大鼠的血清P和LH有抑制作用。
Objective To investigate the anti-early pregnancy activity of prenatal progesterone acetate (ST-1435) in pregnant rats. Methods The pregnant rats were randomly divided into 6 groups on the 8th day of gestation. The rats in the negative control group were injected subcutaneously with normal saline. The rats in the positive control group were treated with mifepristone. The rats in the experimental group were injected subcutaneously with different doses of ST-1435. Each group was sacrificed on the 14th day of pregnancy to observe the pregnancy outcome. Serum progesterone (P) and luteinizing hormone (LH) levels were measured before and after treatment. Results The single injection of 16.0mg / kg dose of ST-1435 anti-pregnancy rate of 83.6%, and mifepristone 12.0mg / kg orally 3 times the anti-pregnancy rate of 84.7% similar to the negative control group was significant Difference (P <0.05). The single-dose anti-pregnancy rates of 8.0 and 4.0 mg / kg ST-1435 were 24.6% and 11.7%, respectively. A single injection of 16.0 or 8.0mg / kgST-1435 on pregnant rats serum LH and P significantly inhibited. Conclusions A single injection of 16.0 mg / kg ST-1435 has similar anti-pregnancy effects as mifepristone 12.0 mg / kg in 3 doses. However, the single administration of ST-1435 at 8.0 and 4.0 mg / kg showed no significant anti-early pregnancy effect. In addition, large doses of ST-1435 on pregnant rats serum P and LH inhibited.