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无绿藻病是一种罕见但近年来发病率逐渐增加的疾病,其临床表现没有明显特征性,诊断主要依靠真菌学检查。本文通过对国际及国内已报道的无绿藻病相关文献分析,归纳其病因、发病机制、临床表现、诊断、治疗及预后;并收集了我国大陆地区10株无绿藻临床分离株,对其进行体外药物敏感性分析,结果证实了两性霉素B作为无绿藻病一线用药的有效性。提示伏立康唑、伊曲康唑及泊沙康唑在无绿藻病治疗中的巨大潜力,也为无绿藻的体外药敏试验分析提供了实验室数据。
Chlorella is a rare but recent increase in the incidence of disease, the clinical manifestations of no obvious characteristic, the diagnosis depends mainly on mycological examination. In this paper, the etiological factors, pathogenesis, clinical manifestations, diagnosis, treatment and prognosis of P. aloe were summarized through literature analysis of both international and domestic reported non-algal algae strains. Ten clinical isolates of P. aloe were collected from mainland China, An in vitro drug susceptibility analysis confirmed the validity of amphotericin B as a first-line agent for algae-free algae. The potential of voriconazole, itraconazole and posaconazole in the treatment of algal unpeeled algae was also suggested. Laboratory data were also provided for in vitro susceptibility testing of P. aloe.