胃、大肠癌手术前后血清急性时相蛋白水平变化的临床意义

• 作 者: 谭亮南 曾跃红 王新华 汤建华
• 机 构: 益阳中心医院检验科
• 出 处: 中国普通外科杂志
• 发表日期: 1999年01期
• 关键词: 急性时相蛋白 大肠癌手术 水平变化 结肠直肠肿瘤 肠癌患者 根治术 外科手术 根治手术 姑息术 急性期蛋白

目的探讨血清急性时相蛋白对胃、大肠癌预后的判断作用。方法对１５０例胃癌和大肠癌患者手术前后血清急性时相蛋白（α１ＡＧ，α１ＡＴ，ＣＲＰ）浓度进行动态观察。结果１５０例胃癌、大肠癌患者术后血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比术前明显降低（Ｐ均＜０．００１），其中１０２例行根治术的术后血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比４８例行姑息术的术后下降更为明显（Ｐ＜０．０１）。１０２例根治手术后随访，３４例术后复发者血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比未复发者明显升高（Ｐ＜０．００１）。结论血清α１ＡＧ，α１ＡＴ，ＣＲＰ可作为胃癌和大肠癌的负荷指标，动态观察其浓度变化，对了解胃癌和大肠癌转移程度，手术疗效评价以及判断预后具有一定意义。

Objective To investigate the effect of serum acute phase protein on the prognosis of gastric and colorectal cancer. Methods The serum acute phase protein (α1AG, α1AT, CRP) concentrations in 150 patients with gastric cancer and colorectal cancer before and after surgery were dynamically observed. Results Serum α1AG,α1AT, and CRP concentrations in 150 patients with gastric cancer and colorectal cancer were significantly lower than those before surgery (all P<0.001). Among them, 102 patients undergoing radical surgery had α1AG, α1 serum after surgery. The reduction of ALT and CRP concentrations in palliative surgery was more pronounced than in 48 patients (P<0.01). In 102 patients who were followed up after radical surgery, serum α1AG, α1AT, and CRP levels were significantly higher in 34 patients with recurrence than those without recurrence (P<0.001). Conclusion Serum α1AG, α1AT and CRP can be used as indicators of gastric cancer and colorectal cancer. Dynamic observation of the concentration of α1AG, α1AT, and CRP can be helpful to understand the degree of metastasis of gastric cancer and colorectal cancer, evaluate surgical outcome, and determine prognosis.